Statins are the most common medications prescribed for treatment of lipid disorders to reduce cardiovascular risk. In this chapter, the types and classes of statins are presented. The major statin trials conducted over the last 30 years are then summarized, with an emphasis on the relation of statin use with cardiovascular disease mortality. Statin doses, metabolism, drug interactions, side effects are then summarized. The chapter concludes with the approach to the patient with statin intolerance.