Immune Constitution of Patients with Brain Tumors


Book Section

© 2017 Elsevier Inc. All rights reserved. Immune deficiencies in patients with glioblastoma (GBM) are not a new discovery. Researchers have been perplexed and challenged by impairments to immunity in the context of GBM dating back to the 1970s. As immunotherapy has become both more studied and more developed, increasing evidence has highlighted factors ranging from lymphopenia to innate and cellular immune dysfunction. Much work has been done to uncover a variety of tumor-inducible mechanisms for limiting the antitumor immune response. In this chapter, we will explore the evolution of our understanding of these immune-restricting mechanisms, as well as strategies for their reversal.

Full Text

Duke Authors

Cited Authors

  • Berry-Candelario, J; Farber, SH; Fecci, PE

Published Date

  • March 2, 2017

Book Title

  • Translational Immunotherapy of Brain Tumors

Start / End Page

  • 13 - 32

International Standard Book Number 13 (ISBN-13)

  • 9780128024201

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-802420-1.00002-8

Citation Source

  • Scopus