A single-shot T2 mapping protocol based on echo-split gradient-spin-echo acquisition and parametric multiplexed sensitivity encoding based on projection onto convex sets reconstruction.


Journal Article

PURPOSE: To develop a high-speed T2 mapping protocol that is capable of accurately measuring T2 relaxation time constants from a single-shot acquisition. THEORY: A new echo-split single-shot gradient-spin-echo (GRASE) pulse sequence is developed to acquire multicontrast data while suppressing signals from most nonprimary echo pathways in Carr-Purcell-Meiboom-Gill (CPMG) echoes. Residual nonprimary pathway signals are taken into consideration when performing T2 mapping using a parametric multiplexed sensitivity encoding based on projection onto convex sets (parametric-POCSMUSE) reconstruction method that incorporates extended phase graph modeling of GRASE signals. METHODS: The single-shot echo-split GRASE-based T2 mapping procedure was evaluated in human studies at 3 Tesla. The acquired data were compared with reference data obtained with a more time-consuming interleaved spin-echo echo planar imaging protocol. T2 maps derived from conventional single-shot GRASE scans, in which nonprimary echo pathways were not appropriately addressed, were also evaluated. RESULTS: Using the developed single-shot T2 mapping protocol, quantitatively accurate T2 maps can be obtained with a short scan time (<0.2 seconds per slice). CONCLUSION: Accurate T2 mapping with minimal signal contamination from CPMG high-order echo pathways can be achieved by the developed method that integrates single-shot echo-split GRASE acquisition and parametric-POCSMUSE reconstruction. Magn Reson Med 79:383-393, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Full Text

Duke Authors

Cited Authors

  • Chu, M-L; Chang, H-C; Oshio, K; Chen, N-K

Published Date

  • January 2018

Published In

Volume / Issue

  • 79 / 1

Start / End Page

  • 383 - 393

PubMed ID

  • 28480603

Pubmed Central ID

  • 28480603

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

Digital Object Identifier (DOI)

  • 10.1002/mrm.26696


  • eng

Conference Location

  • United States