A probabilistic approach to demixing odors.

Published

Journal Article

The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of olfactory receptor neurons, so the central challenge of the olfactory system is to demix its input. Because of noise and the large number of possible odors, demixing is fundamentally a probabilistic inference task. We propose that the early olfactory system uses approximate Bayesian inference to solve it. The computations involve a dynamical loop between the olfactory bulb and the piriform cortex, with cortex explaining incoming activity from the olfactory receptor neurons in terms of a mixture of odors. The model is compatible with known anatomy and physiology, including pattern decorrelation, and it performs better than other models at demixing odors.

Full Text

Duke Authors

Cited Authors

  • Grabska-BarwiƄska, A; Barthelmé, S; Beck, J; Mainen, ZF; Pouget, A; Latham, PE

Published Date

  • January 2017

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 98 - 106

PubMed ID

  • 27918530

Pubmed Central ID

  • 27918530

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.4444

Language

  • eng

Conference Location

  • United States