Langerhans cell histiocytosis presenting as a thyroid gland mass.

Published

Journal Article

We report 2 cases of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. The first case is a 45-year-old woman with a 13-year history of diabetes insipidus who presented with an enlarging thyroid mass with substernal extension. The second case is a 29-year-old man who presented with an enlarging thyroid mass and skin lesions. Histologic evaluation of the thyroid gland in both cases revealed extensive involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a and S-100 protein. Langerhans cell histiocytosis can rarely involve the thyroid gland in adults, and we have identified 30 cases reported in literature. Most patients had evidence of LCH involving other anatomic sites, as was true in these 2 cases, and the diagnosis was initially established by examination of other sites in a subset of patients. Affected patients frequently have diabetes insipidus, as was true in case 1. Thyroid gland involvement as the initial presentation of LCH is a rare phenomenon that can result in misdiagnosis.

Full Text

Duke Authors

Cited Authors

  • Elliott, DD; Sellin, R; Egger, J-F; Medeiros, LJ

Published Date

  • October 2005

Published In

Volume / Issue

  • 9 / 5

Start / End Page

  • 267 - 274

PubMed ID

  • 16198954

Pubmed Central ID

  • 16198954

International Standard Serial Number (ISSN)

  • 1092-9134

Digital Object Identifier (DOI)

  • 10.1016/j.anndiagpath.2005.05.002

Language

  • eng

Conference Location

  • United States