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GBM radiosensitizers: dead in the water…or just the beginning?

Publication ,  Journal Article
Bindra, RS; Chalmers, AJ; Evans, S; Dewhirst, M
Published in: J Neurooncol
September 2017

The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control. Unfortunately, decades of clinical trials testing a wide range of novel therapeutic approaches have failed to yield any clinically viable radiosensitizers. However, many of  the previous radiosensitizing strategies were not based on clear pre-clinical evidence, and in many cases blood-barrier penetration was not considered. Furthermore, DNA repair inhibitors have only recenly arrived in the clinic, and likely represent potent agents for glioma radiosensitization. Here, we present recent progress in the use of small molecule DNA damage response inhibitors as GBM radiosensitizers. In addition, we discuss the latest progress in targeting hypoxia and oxidative stress for GBM radiosensitization.

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Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

September 2017

Volume

134

Issue

3

Start / End Page

513 / 521

Location

United States

Related Subject Headings

  • Radiation-Sensitizing Agents
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Hypoxia
  • Humans
  • Glioblastoma
  • DNA Damage
  • Combined Modality Therapy
  • Brain Neoplasms
  • Animals
 

Citation

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Bindra, R. S., Chalmers, A. J., Evans, S., & Dewhirst, M. (2017). GBM radiosensitizers: dead in the water…or just the beginning? J Neurooncol, 134(3), 513–521. https://doi.org/10.1007/s11060-017-2427-7
Bindra, Ranjit S., Anthony J. Chalmers, Sydney Evans, and Mark Dewhirst. “GBM radiosensitizers: dead in the water…or just the beginning?J Neurooncol 134, no. 3 (September 2017): 513–21. https://doi.org/10.1007/s11060-017-2427-7.
Bindra RS, Chalmers AJ, Evans S, Dewhirst M. GBM radiosensitizers: dead in the water…or just the beginning? J Neurooncol. 2017 Sep;134(3):513–21.
Bindra, Ranjit S., et al. “GBM radiosensitizers: dead in the water…or just the beginning?J Neurooncol, vol. 134, no. 3, Sept. 2017, pp. 513–21. Pubmed, doi:10.1007/s11060-017-2427-7.
Bindra RS, Chalmers AJ, Evans S, Dewhirst M. GBM radiosensitizers: dead in the water…or just the beginning? J Neurooncol. 2017 Sep;134(3):513–521.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

September 2017

Volume

134

Issue

3

Start / End Page

513 / 521

Location

United States

Related Subject Headings

  • Radiation-Sensitizing Agents
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Hypoxia
  • Humans
  • Glioblastoma
  • DNA Damage
  • Combined Modality Therapy
  • Brain Neoplasms
  • Animals