Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.

Published

Journal Article

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.

Full Text

Duke Authors

Cited Authors

  • Moody, MA; Pedroza-Pacheco, I; Vandergrift, NA; Chui, C; Lloyd, KE; Parks, R; Soderberg, KA; Ogbe, AT; Cohen, MS; Liao, H-X; Gao, F; McMichael, AJ; Montefiori, DC; Verkoczy, L; Kelsoe, G; Huang, J; Shea, PR; Connors, M; Borrow, P; Haynes, BF

Published Date

  • July 29, 2016

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • aag0851 -

PubMed ID

  • 28783677

Pubmed Central ID

  • 28783677

Electronic International Standard Serial Number (EISSN)

  • 2470-9468

International Standard Serial Number (ISSN)

  • 2470-9468

Digital Object Identifier (DOI)

  • 10.1126/sciimmunol.aag0851

Language

  • eng