Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.
Moody, MA; Pedroza-Pacheco, I; Vandergrift, NA; Chui, C; Lloyd, KE; Parks, R; Soderberg, KA; Ogbe, AT; Cohen, MS; Liao, H-X; Gao, F; McMichael, AJ; Montefiori, DC; Verkoczy, L; Kelsoe, G; Huang, J; Shea, PR; Connors, M; Borrow, P; Haynes, BF
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