Small but Mighty: Functional Peptides Encoded by Small ORFs in Plants.
Journal Article (Review;Journal Article)
Peptides encoded by small open reading frames (sORFs, usually <100 codons) play critical regulatory roles in plant development and environmental responses. Despite their importance, only a small number of these peptides have been identified and characterized. Genomic studies have revealed that many plant genomes contain thousands of possible sORFs, which could potentially encode small peptides. The challenge is to distinguish translated sORFs from nontranslated ones. Here, we highlight advances in methodologies for identifying these hidden sORFs in plant genomes, including ribosome profiling and proteomics. We also examine the evidence for new peptides arising from sORFs and discuss their functions in plant development, environmental responses, and translational control.
Full Text
Duke Authors
Cited Authors
- Hsu, PY; Benfey, PN
Published Date
- May 2018
Published In
Volume / Issue
- 18 / 10
Start / End Page
- e1700038 -
PubMed ID
- 28759167
Electronic International Standard Serial Number (EISSN)
- 1615-9861
International Standard Serial Number (ISSN)
- 1615-9853
Digital Object Identifier (DOI)
- 10.1002/pmic.201700038
Language
- eng