Small but Mighty: Functional Peptides Encoded by Small ORFs in Plants.
Peptides encoded by small open reading frames (sORFs, usually <100 codons) play critical regulatory roles in plant development and environmental responses. Despite their importance, only a small number of these peptides have been identified and characterized. Genomic studies have revealed that many plant genomes contain thousands of possible sORFs, which could potentially encode small peptides. The challenge is to distinguish translated sORFs from nontranslated ones. Here, we highlight advances in methodologies for identifying these hidden sORFs in plant genomes, including ribosome profiling and proteomics. We also examine the evidence for new peptides arising from sORFs and discuss their functions in plant development, environmental responses, and translational control.
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Related Subject Headings
- Ribosomes
- Proteomics
- Plants
- Peptide Fragments
- Open Reading Frames
- Genomics
- Genome, Plant
- Biochemistry & Molecular Biology
- 32 Biomedical and clinical sciences
- 31 Biological sciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Ribosomes
- Proteomics
- Plants
- Peptide Fragments
- Open Reading Frames
- Genomics
- Genome, Plant
- Biochemistry & Molecular Biology
- 32 Biomedical and clinical sciences
- 31 Biological sciences