Incidence and early course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new insight into the development of ROP.

Full Text

Duke Authors

Cited Authors

  • Palmer, EA; Flynn, JT; Hardy, RJ; Phelps, DL; Phillips, CL; Schaffer, DB; Tung, B

Published Date

  • November 1991

Published In

Volume / Issue

  • 98 / 11

Start / End Page

  • 1628 - 1640

PubMed ID

  • 1800923

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/s0161-6420(91)32074-8


  • eng

Conference Location

  • United States