Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi.


Journal Article

It has been a long-standing debate if sexual development occurs in the microsporidian lineages. Previous studies, including morphological observations, ploidy analysis, and the presence of a sex-related locus, provided evidence of possible extant of sexual development. This study presents another line of evidence by monitoring the parasitophorous vacuoles (PVs) formed by Encephalitozoon cuniculi. Time lapse observations of infection cycles of E. cuniculi revealed that multiple PVs can be formed in a single host cell and the PVs in the single cell can merge (fusion) or split (fission). The dynamics of PVs may provide a route for interactions between genetically distinct microsporidian isolates during host infections.

Full Text

Duke Authors

Cited Authors

  • Lee, SC; Heitman, J

Published Date

  • October 2017

Published In

Volume / Issue

  • 107 /

Start / End Page

  • 20 - 23

PubMed ID

  • 28754285

Pubmed Central ID

  • 28754285

Electronic International Standard Serial Number (EISSN)

  • 1096-0937

Digital Object Identifier (DOI)

  • 10.1016/j.fgb.2017.07.006


  • eng

Conference Location

  • United States