Cell Polarity in Yeast.

Journal Article (Journal Article;Review)

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in diverse organisms. Here we review findings from budding and fission yeasts that reveal both a conserved core polarity circuit and several adaptations that each organism exploits to fulfill the needs of its lifestyle. The core circuit involves positive feedback by local activation of Cdc42 to generate a cluster of concentrated GTP-Cdc42 at the membrane. Species-specific pathways regulate the timing of polarization during the cell cycle, as well as the location and number of polarity sites.

Full Text

Duke Authors

Cited Authors

  • Chiou, J-G; Balasubramanian, MK; Lew, DJ

Published Date

  • October 6, 2017

Published In

Volume / Issue

  • 33 /

Start / End Page

  • 77 - 101

PubMed ID

  • 28783960

Pubmed Central ID

  • PMC5944360

Electronic International Standard Serial Number (EISSN)

  • 1530-8995

Digital Object Identifier (DOI)

  • 10.1146/annurev-cellbio-100616-060856


  • eng

Conference Location

  • United States