Characterization of jet formation and flow field produced by tandem bubbles

Tandem bubble (TB) interactions have been shown to produce directional jets that can be used to create membrane poration on single cells. Jet speed and associated flow field produced around the TB have been postulated to play an important role in TB-induced bioeffects. In this study, dynamics of tandem bubble interaction in a microfluidic channel (25 μm in height) was analyzed by high-speed imaging and simulated using 3DYNAFS-BEM© (DYNAFLOW, INC.). The results suggest that jet size and geometry are primarily controlled by the maximum diameter of the first bubble (D1) while jet speed is about linearly correlated with maximum diameter of the second bubble (D2).

Duke Scholars

Author Pei Zhong Thomas Lord Department of Mechanical Engineering and Materia ...