Alloantibodies: Basic and clinical concepts


Journal Article

The presence of alloantibodies in presensitized transplant candidates has become an increasing problem and results in prolonged waiting time because of the increased risk these patients have of rejecting incompatible donor organs. The destructive effects of antibodies on transplants have been documented by numerous experimental and clinical observations. It is evident now that the pathogenesis of allograft dysfunction and rejection due to alloantibody responses can involve a variety of complex mechanisms that are only partially understood. Moreover, evidence is accumulating that some antibodies may exert protective effects on graft survival in humans; the interaction between protective and destructive antibodies is a dynamic process that will require more investigation before it can be manipulated with certainty. Finally, effective immunosuppressive intervention targeted directly at B lymphocytes or at the generation of alloantibodies remains a challenge for the future. © 1991, All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Baldwin, WM; Pruitt, SK; Sanfilippo, F

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 100 - 119

International Standard Serial Number (ISSN)

  • 0955-470X

Digital Object Identifier (DOI)

  • 10.1016/S0955-470X(10)80036-9

Citation Source

  • Scopus