Extracorporeal portal vein oxygenation improves outcome of acute liver failure in swine.

Published

Journal Article

BACKGROUND: Portal vein arterialization (PVA) has shown efficacy to treat acute liver failure (ALF) in preclinical studies. The next step is to perform large animal studies that propose a clinically acceptable method of PVA. In this study, we assessed the efficacy of PVA using an extracorporeal device to treat 2 ALF models in swine. MATERIALS AND METHODS: The 2 ALF swine models were carbon tetrachloride toxic ALF and subtotal hepatectomy using 8 animals per group. PVA was performed with an extracorporeal device that may be suitable for future clinical studies. Arterial blood was drawn from the iliac artery and delivered into the portal vein for a 6-hour treatment. We analyzed biochemical, blood gas, and histological parameters as well as 1-week survival rates. RESULTS: In both models, ALF was successfully achieved. Control group animals deteriorated biochemically, dropping their prothrombin times and increasing the liver enzymes. In contrast, treated animals improved with a survival rate of 75% at 7 days compared with 0% for the former group. CONCLUSIONS: PVA using an extracorporeal device was feasible and effective to treat both toxic and resective ALF in swine.

Full Text

Cited Authors

  • Nardo, B; Tsivian, M; Neri, F; Piras, G; Pariali, M; Bertelli, R; Cavallari, G

Published Date

  • July 2008

Published In

Volume / Issue

  • 40 / 6

Start / End Page

  • 2046 - 2048

PubMed ID

  • 18675126

Pubmed Central ID

  • 18675126

International Standard Serial Number (ISSN)

  • 0041-1345

Digital Object Identifier (DOI)

  • 10.1016/j.transproceed.2008.05.026

Language

  • eng

Conference Location

  • United States