Regional therapies for in-transit disease.


Journal Article (Review)

In-transit melanoma is an uncommon pattern of recurrence, but presents unique management challenges and opportunities for treatment. The clinical presentation usually involves from 1 to more than 100 small subcutaneous or cutaneous nodules, ranging from submillimeter to multiple centimeters in diameter. Regional chemotherapy techniques are a mainstay of treatment of patients without systemic disease spread. Future applications of regional therapy are likely to involve combination therapy with cytotoxic agents and novel immune modulators. Regional therapy provides distinct opportunities for the treatment of unresectable disease, and offers a unique platform for investigation of novel therapeutics in early-stage clinical trials.

Full Text

Cited Authors

  • Speicher, PJ; Meriwether, CH; Tyler, DS

Published Date

  • April 2015

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 309 - 322

PubMed ID

  • 25769714

Pubmed Central ID

  • 25769714

Electronic International Standard Serial Number (EISSN)

  • 1558-5042

International Standard Serial Number (ISSN)

  • 1055-3207

Digital Object Identifier (DOI)

  • 10.1016/j.soc.2014.12.008


  • eng