Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support.

Journal Article (Journal Article)

BACKGROUND: Right ventricular (RV) failure after left ventricular assist device (LVAD) placement is a serious complication and is difficult to predict. In the era of destination therapy and the total artificial heart, predicting post-LVAD RV failure requiring mechanical support is extremely important. METHODS: We reviewed patient characteristics, laboratory values and hemodynamic data from 266 patients who underwent LVAD placement at the University of Pennsylvania from April 1995 to June 2007. RESULTS: Of 266 LVAD recipients, 99 required RV assist device (BiVAD) placement (37%). We compared 36 parameters between LVAD (n = 167) and BiVAD patients (n = 99) to determine pre-operative risk factors for RV assist device (RVAD) need. By univariate analysis, 23 variables showed statistically significant differences between the two groups (p < or = 0.05). By multivariate logistic regression, cardiac index < or =2.2 liters/min/m(2) (odds ratio [OR] 5.7), RV stroke work index < or =0.25 mm Hg . liter/m(2) (OR 5.1), severe pre-operative RV dysfunction (OR 5.0), pre-operative creatinine > or =1.9 mg/dl (OR 4.8), previous cardiac surgery (OR 4.5) and systolic blood pressure < or =96 mm Hg (OR 2.9) were the best predictors of RVAD need. CONCLUSIONS: The most significant predictors for RVAD need were cardiac index, RV stroke work index, severe pre-operative RV dysfunction, creatinine, previous cardiac surgery and systolic blood pressure. Using these data, we constructed an algorithm that can predict which LVAD patients will require RVAD with >80% sensitivity and specificity.

Full Text

Duke Authors

Cited Authors

  • Fitzpatrick, JR; Frederick, JR; Hsu, VM; Kozin, ED; O'Hara, ML; Howell, E; Dougherty, D; McCormick, RC; Laporte, CA; Cohen, JE; Southerland, KW; Howard, JL; Jessup, ML; Morris, RJ; Acker, MA; Woo, YJ

Published Date

  • December 2008

Published In

Volume / Issue

  • 27 / 12

Start / End Page

  • 1286 - 1292

PubMed ID

  • 19059108

Pubmed Central ID

  • PMC3235680

Electronic International Standard Serial Number (EISSN)

  • 1557-3117

Digital Object Identifier (DOI)

  • 10.1016/j.healun.2008.09.006


  • eng

Conference Location

  • United States