Skip to main content
Journal cover image

Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma.

Publication ,  Journal Article
Jain, V; Phillips, BT; Conkling, N; Pameijer, C
Published in: Int J Surg Oncol
2013

INTRODUCTION: Sentinel lymph node (SLN) biopsy is a vital component of staging and management of multiple cancers. The current gold standard utilizes technetium 99 (tech99) and a blue dye to detect regional nodes. While the success rate is typically over 90%, these two methods can be inconclusive or inconvenient for both patient and surgeon. We evaluated a new technique using laser-assisted ICG dye lymphangiography to identify SLN. METHODS: In this retrospective analysis, we identified patients with melanoma who were candidates for SLN biopsy. In addition to tech99 and methylene blue, patients received a dermal injection of indocyanine green (ICG). The infrared signal was detected with the SPY machine (Novadaq), and nodes positive by any method were excised. RESULTS: A total of 15 patients were evaluated, with 40 SLNs removed. Four patients were found to have nodal metastases on final pathology. 100% of these 4 nodes were identified by ICG, while only 75% (3/4) were positive for tech99 and/or methylene blue. Furthermore, none of the nodes missed by ICG (4/40) had malignant cells. CONCLUSION: ICG dye lymphangiography is a reasonable alternative for locating SLNs in patients with melanoma. Prospective studies are needed to better ascertain the full functionality of this technique.

Duke Scholars

Published In

Int J Surg Oncol

DOI

ISSN

2090-1402

Publication Date

2013

Volume

2013

Start / End Page

904214

Location

United States

Related Subject Headings

  • Technetium
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Retrospective Studies
  • Middle Aged
  • Methylene Blue
  • Melanoma
  • Lymphography
  • Lymphatic Metastasis
  • Lymph Nodes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jain, V., Phillips, B. T., Conkling, N., & Pameijer, C. (2013). Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma. Int J Surg Oncol, 2013, 904214. https://doi.org/10.1155/2013/904214
Jain, Vikalp, Brett T. Phillips, Nicole Conkling, and Colette Pameijer. “Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma.Int J Surg Oncol 2013 (2013): 904214. https://doi.org/10.1155/2013/904214.
Jain V, Phillips BT, Conkling N, Pameijer C. Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma. Int J Surg Oncol. 2013;2013:904214.
Jain, Vikalp, et al. “Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma.Int J Surg Oncol, vol. 2013, 2013, p. 904214. Pubmed, doi:10.1155/2013/904214.
Jain V, Phillips BT, Conkling N, Pameijer C. Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma. Int J Surg Oncol. 2013;2013:904214.
Journal cover image

Published In

Int J Surg Oncol

DOI

ISSN

2090-1402

Publication Date

2013

Volume

2013

Start / End Page

904214

Location

United States

Related Subject Headings

  • Technetium
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Retrospective Studies
  • Middle Aged
  • Methylene Blue
  • Melanoma
  • Lymphography
  • Lymphatic Metastasis
  • Lymph Nodes