Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma.

Published

Journal Article

INTRODUCTION: Sentinel lymph node (SLN) biopsy is a vital component of staging and management of multiple cancers. The current gold standard utilizes technetium 99 (tech99) and a blue dye to detect regional nodes. While the success rate is typically over 90%, these two methods can be inconclusive or inconvenient for both patient and surgeon. We evaluated a new technique using laser-assisted ICG dye lymphangiography to identify SLN. METHODS: In this retrospective analysis, we identified patients with melanoma who were candidates for SLN biopsy. In addition to tech99 and methylene blue, patients received a dermal injection of indocyanine green (ICG). The infrared signal was detected with the SPY machine (Novadaq), and nodes positive by any method were excised. RESULTS: A total of 15 patients were evaluated, with 40 SLNs removed. Four patients were found to have nodal metastases on final pathology. 100% of these 4 nodes were identified by ICG, while only 75% (3/4) were positive for tech99 and/or methylene blue. Furthermore, none of the nodes missed by ICG (4/40) had malignant cells. CONCLUSION: ICG dye lymphangiography is a reasonable alternative for locating SLNs in patients with melanoma. Prospective studies are needed to better ascertain the full functionality of this technique.

Full Text

Duke Authors

Cited Authors

  • Jain, V; Phillips, BT; Conkling, N; Pameijer, C

Published Date

  • 2013

Published In

Volume / Issue

  • 2013 /

Start / End Page

  • 904214 -

PubMed ID

  • 24382997

Pubmed Central ID

  • 24382997

International Standard Serial Number (ISSN)

  • 2090-1402

Digital Object Identifier (DOI)

  • 10.1155/2013/904214

Language

  • eng

Conference Location

  • United States