Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas.

Journal Article (Journal Article;Review)

Brainstem gliomas comprise 10-20% of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and a median survival less than 12 months. Current standard-of-care treatment for DIPG includes radiation therapy, but its long-term survival effects are still under debate. Clinical trials investigating the efficacy of systemic administration of various therapeutic agents have been associated with disappointing outcomes. Recent efforts have focused on improvements in chemotherapeutic agents employed and in methods of localized and targeted drug delivery. This review provides an update on current preclinical and clinical studies investigating treatment options for brainstem gliomas.

Full Text

Duke Authors

Cited Authors

  • Goodwin, CR; Xu, R; Iyer, R; Sankey, EW; Liu, A; Abu-Bonsrah, N; Sarabia-Estrada, R; Frazier, JL; Sciubba, DM; Jallo, GI

Published Date

  • March 2016

Published In

Volume / Issue

  • 142 /

Start / End Page

  • 120 - 127

PubMed ID

  • 26849840

Electronic International Standard Serial Number (EISSN)

  • 1872-6968

Digital Object Identifier (DOI)

  • 10.1016/j.clineuro.2016.01.007


  • eng

Conference Location

  • Netherlands