Extraneural Glioblastoma Multiforme Vertebral Metastasis.

Journal Article (Journal Article;Review)

Glioblastoma multiforme (GBM) is the most common malignant central nervous system tumor; however, extraneural metastasis is uncommon. Of those that metastasize extraneurally, metastases to the vertebral bodies represent a significant proportion. We present a review of 28 cases from the published literature of GBM metastasis to the vertebra. The mean age at presentation was 38.4 years with an average overall survival of 26 months. Patients were either asymptomatic with metastasis discovered at autopsy or presented with varying degrees of pain, weakness of the extremities, or other neurologic deficits. Of the cases that included the time to spinal metastasis, the average time was 26.4 months with a reported survival of 10 months after diagnosis of vertebral metastasis. A significant number of patients had no treatments for their spinal metastasis, although the intracranial lesions were treated extensively with surgery and/or adjuvant therapy. With increasing incremental gains in the survival of patients with GBM, clinicians will encounter patients with extracranial metastasis. As such, this review presents timely information concerning the presentation and outcomes of patients with vertebral metastasis.

Full Text

Duke Authors

Cited Authors

  • Goodwin, CR; Liang, L; Abu-Bonsrah, N; Hdeib, A; Elder, BD; Kosztowski, T; Bettegowda, C; Laterra, J; Burger, P; Sciubba, DM

Published Date

  • May 2016

Published In

Volume / Issue

  • 89 /

Start / End Page

  • 578 - 582.e3

PubMed ID

  • 26704201

Pubmed Central ID

  • PMC4870129

Electronic International Standard Serial Number (EISSN)

  • 1878-8769

Digital Object Identifier (DOI)

  • 10.1016/j.wneu.2015.11.061


  • eng

Conference Location

  • United States