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A systematic assessment of the use of platelet-rich plasma in spinal fusion.

Publication ,  Journal Article
Elder, BD; Holmes, C; Goodwin, CR; Lo, S-F; Puvanesarajah, V; Kosztowski, TA; Locke, JE; Witham, TF
Published in: Ann Biomed Eng
May 2015

Spinal fusion is one of the most commonly performed procedures for the treatment of spinal instability caused by a multitude of pathologies. However, despite significant advances in spinal instrumentation, failed fusion, or pseudoarthrosis, remains a significant challenge. Therefore, other additives such as bone graft extenders and growth factors have been explored as a method to augment fusion rates. Platelet-rich plasma (PRP) represents an additional approach, as it has shown some promise in bone regeneration. While the general use of PRP in orthopedic applications has been reviewed previously, its use in spinal fusion has not been systematically analyzed. The objective of this review is to systematically discuss the role of PRP in augmentation of bone regeneration for the purpose of spinal fusion. Background information on PRP, including a discussion of its preparation, activation, and growth factors, is included. Additionally, data from in vitro studies utilizing PRP in bone tissue engineering strategies is analyzed, and the available animal and clinical studies are systematically reviewed in order to provide guidance on future research pathways as well as the potential role of PRP in spinal fusion surgery.

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Published In

Ann Biomed Eng

DOI

EISSN

1573-9686

Publication Date

May 2015

Volume

43

Issue

5

Start / End Page

1057 / 1070

Location

United States

Related Subject Headings

  • Spinal Fusion
  • Platelet-Rich Plasma
  • Humans
  • Biomedical Engineering
  • Animals
  • 4003 Biomedical engineering
  • 11 Medical and Health Sciences
  • 09 Engineering
 

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Elder, B. D., Holmes, C., Goodwin, C. R., Lo, S.-F., Puvanesarajah, V., Kosztowski, T. A., … Witham, T. F. (2015). A systematic assessment of the use of platelet-rich plasma in spinal fusion. Ann Biomed Eng, 43(5), 1057–1070. https://doi.org/10.1007/s10439-015-1300-0
Elder, Benjamin D., Christina Holmes, C Rory Goodwin, Sheng-Fu Lo, Varun Puvanesarajah, Thomas A. Kosztowski, John E. Locke, and Timothy F. Witham. “A systematic assessment of the use of platelet-rich plasma in spinal fusion.Ann Biomed Eng 43, no. 5 (May 2015): 1057–70. https://doi.org/10.1007/s10439-015-1300-0.
Elder BD, Holmes C, Goodwin CR, Lo S-F, Puvanesarajah V, Kosztowski TA, et al. A systematic assessment of the use of platelet-rich plasma in spinal fusion. Ann Biomed Eng. 2015 May;43(5):1057–70.
Elder, Benjamin D., et al. “A systematic assessment of the use of platelet-rich plasma in spinal fusion.Ann Biomed Eng, vol. 43, no. 5, May 2015, pp. 1057–70. Pubmed, doi:10.1007/s10439-015-1300-0.
Elder BD, Holmes C, Goodwin CR, Lo S-F, Puvanesarajah V, Kosztowski TA, Locke JE, Witham TF. A systematic assessment of the use of platelet-rich plasma in spinal fusion. Ann Biomed Eng. 2015 May;43(5):1057–1070.
Journal cover image

Published In

Ann Biomed Eng

DOI

EISSN

1573-9686

Publication Date

May 2015

Volume

43

Issue

5

Start / End Page

1057 / 1070

Location

United States

Related Subject Headings

  • Spinal Fusion
  • Platelet-Rich Plasma
  • Humans
  • Biomedical Engineering
  • Animals
  • 4003 Biomedical engineering
  • 11 Medical and Health Sciences
  • 09 Engineering