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Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes.

Publication ,  Journal Article
Albini, TA; Abd-El-Barr, MM; Carvounis, PE; Iyer, MN; Lakhanpal, RR; Pennesi, ME; Chevez-Barrios, P; Wu, SM; Holz, ER
Published in: Invest Ophthalmol Vis Sci
January 2007

PURPOSE: To investigate whether intravitreal Kenalog (IVTK; Bristol Meyers Squibb Company, Princeton, NJ) produces histologic or electroretinographic changes in the rabbit retina up to 3 months after injection. METHODS: Ten Dutch-belted rabbits were injected with 4 mg/0.1 mL Kenalog in one eye and 0.1 mL physiologic salt solution (PSS) in the fellow eye. Simultaneous bilateral dark-adapted electroretinography was performed 2 weeks and 12 weeks after injection in 10 and 6 rabbits, respectively. Saturated a-wave amplitude, maximal scotopic b-wave amplitude, and individual a-wave and b-wave amplitudes of IVTK-injected and control eyes were compared at 2 and 12 weeks after injection. Light microscopy was performed on both eyes of three animals 3 months after injection. Immunohistochemistry was performed with antibodies recognizing vimentin and human alveolar macrophage (HAM)-56, markers of glial cells and macrophages, respectively. RESULTS: No significant difference was observed in the saturated a-wave or maximal scotopic b-wave amplitudes between the PSS-injected eyes and the IVTK-injected eyes at 2 weeks (P = 0.95 and P = 0.56, respectively) and 12 weeks (P = 0.82 and P = 0.17) after injection. Light microscopy and immunohistochemistry disclosed only rare macrophages in the vitreous of IVTK-injected eyes. Retinal layers, retinal pigment epithelium, and choriocapillaris in treatment and control eyes were unremarkable. CONCLUSIONS: No demonstrable electroretinographic or histologic changes occurred to suggest immediate or delayed widespread retinal toxicity of IVTK.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

ISSN

0146-0404

Publication Date

January 2007

Volume

48

Issue

1

Start / End Page

390 / 395

Location

United States

Related Subject Headings

  • Vitreous Body
  • Vimentin
  • Triamcinolone Acetonide
  • Retina
  • Rabbits
  • Preservatives, Pharmaceutical
  • Ophthalmology & Optometry
  • Neuroglia
  • Macrophages
  • Injections
 

Citation

APA
Chicago
ICMJE
MLA
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Albini, T. A., Abd-El-Barr, M. M., Carvounis, P. E., Iyer, M. N., Lakhanpal, R. R., Pennesi, M. E., … Holz, E. R. (2007). Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes. Invest Ophthalmol Vis Sci, 48(1), 390–395. https://doi.org/10.1167/iovs.06-0145
Albini, Thomas A., Muhammad M. Abd-El-Barr, Petros E. Carvounis, Mohan N. Iyer, Rohit R. Lakhanpal, Mark E. Pennesi, Patricia Chevez-Barrios, Samuel M. Wu, and Eric R. Holz. “Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes.Invest Ophthalmol Vis Sci 48, no. 1 (January 2007): 390–95. https://doi.org/10.1167/iovs.06-0145.
Albini TA, Abd-El-Barr MM, Carvounis PE, Iyer MN, Lakhanpal RR, Pennesi ME, et al. Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):390–5.
Albini, Thomas A., et al. “Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes.Invest Ophthalmol Vis Sci, vol. 48, no. 1, Jan. 2007, pp. 390–95. Pubmed, doi:10.1167/iovs.06-0145.
Albini TA, Abd-El-Barr MM, Carvounis PE, Iyer MN, Lakhanpal RR, Pennesi ME, Chevez-Barrios P, Wu SM, Holz ER. Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):390–395.

Published In

Invest Ophthalmol Vis Sci

DOI

ISSN

0146-0404

Publication Date

January 2007

Volume

48

Issue

1

Start / End Page

390 / 395

Location

United States

Related Subject Headings

  • Vitreous Body
  • Vimentin
  • Triamcinolone Acetonide
  • Retina
  • Rabbits
  • Preservatives, Pharmaceutical
  • Ophthalmology & Optometry
  • Neuroglia
  • Macrophages
  • Injections