Estimated Tris(1,3-dichloro-2-propyl) Phosphate Exposure Levels for U.S. Infants Suggest Potential Health Risks


Journal Article

© 2017 American Chemical Society. Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been widely used as a flame retardant and is commonly detected in environmental samples. Biomonitoring studies relying on urinary metabolite levels [i.e., bis(1,3-dichloro-2-propyl) phosphate (BDCIPP)] demonstrate widespread exposure, but TDCIPP intake is unknown. Intake data are critical components of meaningful risk assessments and are needed to elucidate the potential health impacts of TDCIPP exposure. Using biomonitoring data, we estimated TDCIPP intake for infants aged 2-18 months. Children were recruited from central North Carolina (n = 43, recruited in 2014 and 2015), and spot urine samples were analyzed for BDCIPP. TDCIPP intake rates were estimated using daily urine excretion and the fraction of TDCIPP excreted as BDCIPP in urine. Daily TDCIPP intake estimates ranged from 0.01 to 15.03 μg kg-1 day-1 for children included in our assessment, with some variation depending on model assumptions. The U.S. Consumer Products Safety Commission previously established an acceptable daily intake of 5 μg kg-1 day-1 for non-cancer health risks. Depending on modeling assumptions, we found that 2-9% percent of infants had TDCIPP intake estimates above this threshold. Our results indicate that current TDCIPP exposure levels could pose health risks for highly exposed infants.

Full Text

Duke Authors

Cited Authors

  • Hoffman, K; Gearhart-Serna, L; Lorber, M; Webster, TF; Stapleton, HM

Published Date

  • August 8, 2017

Published In

Volume / Issue

  • 4 / 8

Start / End Page

  • 334 - 338

Electronic International Standard Serial Number (EISSN)

  • 2328-8930

Digital Object Identifier (DOI)

  • 10.1021/acs.estlett.7b00196

Citation Source

  • Scopus