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Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques.

Publication ,  Journal Article
Phillips, B; Fouda, GG; Eudailey, J; Pollara, J; Curtis, AD; Kunz, E; Dennis, M; Shen, X; Bay, C; Hudgens, M; Pickup, D; Alam, SM; Ferrari, G ...
Published in: Clin Vaccine Immunol
October 2017

Despite success in reducing vertical HIV transmission by maternal antiretroviral therapy, several obstacles limit its efficacy during breastfeeding, and breast-milk transmission is now the dominant mode of mother-to-child transmission (MTCT) of HIV in infants. Thus, a pediatric vaccine is needed to eradicate oral HIV infections in newborns and infants. Utilizing the infant rhesus macaque model, we compared 3 different vaccine regimens: (i) HIV envelope (Env) protein only, (ii) poxvirus vector (modified vaccinia virus Ankara [MVA])-HIV Env prime and HIV Env boost, and (iii) coadministration of HIV Env and MVA-HIV Env at all time points. The vaccines were administered with an accelerated, 3-week-interval regimen starting at birth for early induction of highly functional HIV Env-specific antibodies. We also tested whether an extended, 6-week immunization interval using the same vaccine regimen as in the coadministration group would enhance the quality of antibody responses. We found that pediatric HIV vaccines administered at birth are effective in inducing HIV Env-specific plasma IgG. The vaccine regimen consisting of only HIV Env protein induced the highest levels of variable region 1 and 2 (V1V2)-specific antibodies and tier 1 neutralizing antibodies, whereas the extended-interval regimen induced both persistent Env-specific systemic IgG and mucosal IgA responses. Antibody-dependent cell-mediated cytotoxicity (ADCC) antibodies in plasma were elicited by all vaccine regimens. These data suggest that infant immunizations beginning at birth are effective for the induction of functional HIV Env-specific antibodies that could potentially protect against breast milk transmission of HIV and set the stage for immunity prior to sexual debut.

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Published In

Clin Vaccine Immunol

DOI

EISSN

1556-679X

Publication Date

October 2017

Volume

24

Issue

10

Location

United States

Related Subject Headings

  • Vaccinia virus
  • Vaccines, Synthetic
  • Vaccines, DNA
  • Vaccination
  • Models, Animal
  • Microbiology
  • Macaca mulatta
  • Infectious Disease Transmission, Vertical
  • Immunology
  • Immunoglobulin A
 

Citation

APA
Chicago
ICMJE
MLA
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Phillips, B., Fouda, G. G., Eudailey, J., Pollara, J., Curtis, A. D., Kunz, E., … De Paris, K. (2017). Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. Clin Vaccine Immunol, 24(10). https://doi.org/10.1128/CVI.00231-17
Phillips, Bonnie, Genevieve G. Fouda, Josh Eudailey, Justin Pollara, Alan D. Curtis, Erika Kunz, Maria Dennis, et al. “Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques.Clin Vaccine Immunol 24, no. 10 (October 2017). https://doi.org/10.1128/CVI.00231-17.
Phillips B, Fouda GG, Eudailey J, Pollara J, Curtis AD, Kunz E, et al. Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. Clin Vaccine Immunol. 2017 Oct;24(10).
Phillips, Bonnie, et al. “Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques.Clin Vaccine Immunol, vol. 24, no. 10, Oct. 2017. Pubmed, doi:10.1128/CVI.00231-17.
Phillips B, Fouda GG, Eudailey J, Pollara J, Curtis AD, Kunz E, Dennis M, Shen X, Bay C, Hudgens M, Pickup D, Alam SM, Ardeshir A, Kozlowski PA, Van Rompay KKA, Ferrari G, Moody MA, Permar S, De Paris K. Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. Clin Vaccine Immunol. 2017 Oct;24(10).

Published In

Clin Vaccine Immunol

DOI

EISSN

1556-679X

Publication Date

October 2017

Volume

24

Issue

10

Location

United States

Related Subject Headings

  • Vaccinia virus
  • Vaccines, Synthetic
  • Vaccines, DNA
  • Vaccination
  • Models, Animal
  • Microbiology
  • Macaca mulatta
  • Infectious Disease Transmission, Vertical
  • Immunology
  • Immunoglobulin A