Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.
Journal Article (Journal Article)
In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin's control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size.
Full Text
Duke Authors
Cited Authors
- Di Mambro, R; De Ruvo, M; Pacifici, E; Salvi, E; Sozzani, R; Benfey, PN; Busch, W; Novak, O; Ljung, K; Di Paola, L; Marée, AFM; Costantino, P; Grieneisen, VA; Sabatini, S
Published Date
- September 2017
Published In
Volume / Issue
- 114 / 36
Start / End Page
- E7641 - E7649
PubMed ID
- 28831001
Pubmed Central ID
- PMC5594665
Electronic International Standard Serial Number (EISSN)
- 1091-6490
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.1705833114
Language
- eng