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The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study.

Publication ,  Journal Article
Grotegut, CA; Lewis, LL; Manuck, TA; Allen, TK; James, AH; Seco, A; Deneux-Tharaux, C
Published in: Am J Perinatol
January 2018

OBJECTIVE: Total dose of oxytocin received during labor is an important variable in studies of human labor but is difficult to calculate. We sought to identify a surrogate measure for total dose of oxytocin received. STUDY DESIGN: For each subject receiving oxytocin during labor, the oxytocin total dose received in labor was calculated as the area under the curve. Maximal oxytocin infusion rate, total duration of oxytocin infusion, and the product of both, defined as the oxytocin product, were then each correlated with the total dose of oxytocin received using the Pearson's correlation coefficient. RESULTS: Oxytocin dosing data were available from 402 women at Duke and 6,907 women from Pithagore6. The two variables alone, or combined as the oxytocin product, demonstrated a high correlation with the oxytocin total dose (r > 0.7), with the oxytocin product demonstrating the highest (r > 0.9). This was true whether labor was induced or augmented and whether delivery was vaginal or cesarean. CONCLUSION: The oxytocin product, composed of two easily obtained variables, demonstrated a very high correlation with total oxytocin dose received in labor and represents a simple and accurate surrogate for total dose of oxytocin received during labor. The oxytocin product can be used in clinical studies in which oxytocin dose is an important variable.

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

January 2018

Volume

35

Issue

1

Start / End Page

78 / 83

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Pregnancy
  • Oxytocin
  • Oxytocics
  • Obstetrics & Reproductive Medicine
  • Labor, Obstetric
  • Labor, Induced
  • Humans
  • Female
 

Citation

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Chicago
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Grotegut, C. A., Lewis, L. L., Manuck, T. A., Allen, T. K., James, A. H., Seco, A., & Deneux-Tharaux, C. (2018). The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study. Am J Perinatol, 35(1), 78–83. https://doi.org/10.1055/s-0037-1606119
Grotegut, Chad A., Lauren L. Lewis, Tracy A. Manuck, Terrence K. Allen, Andra H. James, Aurelien Seco, and Catherine Deneux-Tharaux. “The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study.Am J Perinatol 35, no. 1 (January 2018): 78–83. https://doi.org/10.1055/s-0037-1606119.
Grotegut CA, Lewis LL, Manuck TA, Allen TK, James AH, Seco A, et al. The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study. Am J Perinatol. 2018 Jan;35(1):78–83.
Grotegut, Chad A., et al. “The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study.Am J Perinatol, vol. 35, no. 1, Jan. 2018, pp. 78–83. Pubmed, doi:10.1055/s-0037-1606119.
Grotegut CA, Lewis LL, Manuck TA, Allen TK, James AH, Seco A, Deneux-Tharaux C. The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study. Am J Perinatol. 2018 Jan;35(1):78–83.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

January 2018

Volume

35

Issue

1

Start / End Page

78 / 83

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Pregnancy
  • Oxytocin
  • Oxytocics
  • Obstetrics & Reproductive Medicine
  • Labor, Obstetric
  • Labor, Induced
  • Humans
  • Female