Breast dose reduction with organ-based, wide-angle tube current modulated CT.

Journal Article (Journal Article)

This study aimed to estimate the organ dose reduction potential for organ-dose-based tube current modulated (ODM) thoracic computed tomography (CT) with a wide dose reduction arc. Twenty-one computational anthropomorphic phantoms (XCAT) were used to create a virtual patient population with clinical anatomic variations. The phantoms were created based on patient images with normal anatomy (age range: 27 to 66 years, weight range: 52.0 to 105.8 kg). For each phantom, two breast tissue compositions were simulated: [Formula: see text] and [Formula: see text] (glandular-to-adipose ratio). A validated Monte Carlo program (PENELOPE, Universitat de Barcelona, Spain) was used to estimate the organ dose for standard tube current modulation (TCM) (SmartmA, GE Healthcare) and ODM (GE Healthcare) for a commercial CT scanner (Revolution, GE Healthcare) using a typical clinical thoracic CT protocol. Both organ dose and [Formula: see text]-to-organ dose conversion coefficients ([Formula: see text] factors) were compared between TCM and ODM. ODM significantly reduced all radiosensitive organ doses ([Formula: see text]). The breast dose was reduced by [Formula: see text]. For [Formula: see text] factors, organs in the anterior region (e.g., thyroid and stomach) exhibited substantial decreases, and the medial, distributed, and posterior region saw either an increase of less than 5% or no significant change. ODM significantly reduced organ doses especially for radiosensitive superficial anterior organs such as the breasts.

Full Text

Duke Authors

Cited Authors

  • Fu, W; Sturgeon, GM; Agasthya, G; Segars, WP; Kapadia, AJ; Samei, E

Published Date

  • July 2017

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 031208 -

PubMed ID

  • 28804730

Pubmed Central ID

  • PMC5544175

International Standard Serial Number (ISSN)

  • 2329-4302

Digital Object Identifier (DOI)

  • 10.1117/1.JMI.4.3.031208


  • eng

Conference Location

  • United States