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Synthesis of Cationic Amphiphilic Surface-Block Polyester Dendrimers

Publication ,  Journal Article
Prata, CAH; Luman, NR; Li, Y; Luo, D; McIntosh, TJ; Barthélémy, P; Grinstaff, MW
Published in: Journal of Inorganic and Organometallic Polymers and Materials
March 1, 2018

Cationic amphiphilic polyester dendrimers possessing varied numbers of choline and alkyl chains on the periphery were synthesized and characterized. A combination of divergent and convergent synthetic routes was used to efficiently prepare the dendrimers. All of the amphiphiles bound DNA as determined by an ethidium bromide displacement assay, and the dendrimer that contained two choline and four alkyl chains exhibited the smallest charge ratio. Only this amphiphilic dendrimer formed a well-defined structure alone or with DNA in solution, while the other dendrimer compositions gave aggregates. Specifically, small vesicular structures of several 100 nanometers in diameter were observed with DNA, and this dendrimerplex exhibited the greatest transfection efficiency of the group. The results of this study highlight the important role that charge, hydrophobicity, size, and compaction ability play in binding and formation of DNA-dendrimer complexes and the resulting transfection efficiency. Graphical Abstract: Cationic amphiphilic polyester dendrimers possessing different numbers of choline heads groups and myristic acid alkyl chains were synthesized and evaluated for gene transfection. [Figure not available: see fulltext.].

Duke Scholars

Published In

Journal of Inorganic and Organometallic Polymers and Materials

DOI

EISSN

1574-1451

ISSN

1574-1443

Publication Date

March 1, 2018

Volume

28

Issue

2

Start / End Page

383 / 398

Related Subject Headings

  • Polymers
  • 4016 Materials engineering
  • 3403 Macromolecular and materials chemistry
  • 3402 Inorganic chemistry
 

Citation

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Prata, C. A. H., Luman, N. R., Li, Y., Luo, D., McIntosh, T. J., Barthélémy, P., & Grinstaff, M. W. (2018). Synthesis of Cationic Amphiphilic Surface-Block Polyester Dendrimers. Journal of Inorganic and Organometallic Polymers and Materials, 28(2), 383–398. https://doi.org/10.1007/s10904-017-0651-4
Prata, C. A. H., N. R. Luman, Y. Li, D. Luo, T. J. McIntosh, P. Barthélémy, and M. W. Grinstaff. “Synthesis of Cationic Amphiphilic Surface-Block Polyester Dendrimers.” Journal of Inorganic and Organometallic Polymers and Materials 28, no. 2 (March 1, 2018): 383–98. https://doi.org/10.1007/s10904-017-0651-4.
Prata CAH, Luman NR, Li Y, Luo D, McIntosh TJ, Barthélémy P, et al. Synthesis of Cationic Amphiphilic Surface-Block Polyester Dendrimers. Journal of Inorganic and Organometallic Polymers and Materials. 2018 Mar 1;28(2):383–98.
Prata, C. A. H., et al. “Synthesis of Cationic Amphiphilic Surface-Block Polyester Dendrimers.” Journal of Inorganic and Organometallic Polymers and Materials, vol. 28, no. 2, Mar. 2018, pp. 383–98. Scopus, doi:10.1007/s10904-017-0651-4.
Prata CAH, Luman NR, Li Y, Luo D, McIntosh TJ, Barthélémy P, Grinstaff MW. Synthesis of Cationic Amphiphilic Surface-Block Polyester Dendrimers. Journal of Inorganic and Organometallic Polymers and Materials. 2018 Mar 1;28(2):383–398.
Journal cover image

Published In

Journal of Inorganic and Organometallic Polymers and Materials

DOI

EISSN

1574-1451

ISSN

1574-1443

Publication Date

March 1, 2018

Volume

28

Issue

2

Start / End Page

383 / 398

Related Subject Headings

  • Polymers
  • 4016 Materials engineering
  • 3403 Macromolecular and materials chemistry
  • 3402 Inorganic chemistry