Defining Papillary Carcinoma of the Thyroid: A Short Review and Analysis.

Published

Journal Article

Objectives:To review how changes in the pathologic definitions for papillary tumors of the thyroid during recent decades have affected outcomes for patients with these tumors. Methods:Forty-nine previous reports or studies involving collectively 53,606 patients were reviewed, and new analyses were performed on the data to include analyses of agreement, incidence, survival, and diagnostic categories. Results:The past emphasis on cytologic features to define papillary tumors has not resulted in ideal pairwise agreement between pathologists and has produced incidence and survival data suggesting overdetection and overdiagnosis. Most recently, tissue patterns have been reemphasized. Conclusions:With the recent reemphasis on diagnostic tissue patterns (over cytologic criteria), agreements between pathologists for the diagnosis of papillary tumors should improve, and the incidence of papillary carcinoma should decline. Nevertheless, updated survival analyses demonstrate excellent long-term survival for most of those diagnosed with papillary carcinomas.

Full Text

Duke Authors

Cited Authors

  • Vollmer, RT

Published Date

  • August 2017

Published In

Volume / Issue

  • 148 / 2

Start / End Page

  • 100 - 107

PubMed ID

  • 28898991

Pubmed Central ID

  • 28898991

Electronic International Standard Serial Number (EISSN)

  • 1943-7722

International Standard Serial Number (ISSN)

  • 0002-9173

Digital Object Identifier (DOI)

  • 10.1093/ajcp/aqx051

Language

  • eng