Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study.

Journal Article (Journal Article;Multicenter Study)

Thirty percent of kidney transplant recipients are readmitted in the first month posttransplantation. Those with donor-specific antibody requiring desensitization and incompatible live donor kidney transplantation (ILDKT) constitute a unique subpopulation that might be at higher readmission risk. Drawing on a 22-center cohort, 379 ILDKTs with Medicare primary insurance were matched to compatible transplant-matched controls and to waitlist-only matched controls on panel reactive antibody, age, blood group, renal replacement time, prior kidney transplantation, race, gender, diabetes, and transplant date/waitlisting date. Readmission risk was determined using multilevel, mixed-effects Poisson regression. In the first month, ILDKTs had a 1.28-fold higher readmission risk than compatible controls (95% confidence interval [CI] 1.13-1.46; P < .001). Risk peaked at 6-12 months (relative risk [RR] 1.67, 95% CI 1.49-1.87; P < .001), attenuating by 24-36 months (RR 1.24, 95% CI 1.10-1.40; P < .001). ILDKTs had a 5.86-fold higher readmission risk (95% CI 4.96-6.92; P < .001) in the first month compared to waitlist-only controls. At 12-24 (RR 0.85, 95% CI 0.77-0.95; P = .002) and 24-36 months (RR 0.74, 95% CI 0.66-0.84; P < .001), ILDKTs had a lower risk than waitlist-only controls. These findings of ILDKTs having a higher readmission risk than compatible controls, but a lower readmission risk after the first year than waitlist-only controls should be considered in regulatory/payment schemas and planning clinical care.

Full Text

Duke Authors

Cited Authors

  • Orandi, BJ; Luo, X; King, EA; Garonzik-Wang, JM; Bae, S; Montgomery, RA; Stegall, MD; Jordan, SC; Oberholzer, J; Dunn, TB; Ratner, LE; Kapur, S; Pelletier, RP; Roberts, JP; Melcher, ML; Singh, P; Sudan, DL; Posner, MP; El-Amm, JM; Shapiro, R; Cooper, M; Lipkowitz, GS; Rees, MA; Marsh, CL; Sankari, BR; Gerber, DA; Nelson, PW; Wellen, J; Bozorgzadeh, A; Osama Gaber, A; Segev, DL

Published Date

  • March 2018

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 650 - 658

PubMed ID

  • 28834181

Pubmed Central ID

  • PMC5820188

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

Digital Object Identifier (DOI)

  • 10.1111/ajt.14472


  • eng

Conference Location

  • United States