Meningococcal tetravalent conjugate vaccine.

Journal Article (Journal Article;Review)

BACKGROUND: Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. Since 1981, a tetravalent meningococcal polysaccharide vaccine has been available in the US but it has been limited to high-risk patients and outbreak settings. In 2005, a tetravalent polysaccharide meningococcal conjugate vaccine (MCV4) was licensed for routine use in the US. OBJECTIVE: To assess the immunogenicity and safety of MCV4, and to extrapolate the anticipated clinical effectiveness of MCV4 using data from other polysaccharide conjugate vaccination programs. METHODS: All published controlled studies of MCV4 immunogenicity, safety and cost-effectiveness are analyzed. Publicly-available clinical trial data and the Advisory Committee on Immunization Practices guidelines were also reviewed. CONCLUSION: MCV4 is as safe and immunogenic as the previously available polysaccharide vaccine, and seems to provide longer lasting protection against meningococcal disease. Long-term studies are continuing and will shed further light on the effectiveness of MCV4 at the population level.

Full Text

Duke Authors

Cited Authors

  • Smith, MJ

Published Date

  • December 2008

Published In

Volume / Issue

  • 8 / 12

Start / End Page

  • 1941 - 1946

PubMed ID

  • 18990080

Pubmed Central ID

  • 18990080

Electronic International Standard Serial Number (EISSN)

  • 1744-7682

Digital Object Identifier (DOI)

  • 10.1517/14712590802538455


  • eng

Conference Location

  • England