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Immune regulation by glucocorticoids.

Publication ,  Journal Article
Cain, DW; Cidlowski, JA
Published in: Nat Rev Immunol
April 2017

Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.

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Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

April 2017

Volume

17

Issue

4

Start / End Page

233 / 247

Location

England

Related Subject Headings

  • Inflammation
  • Immunosuppressive Agents
  • Immunology
  • Immune System
  • Humans
  • Glucocorticoids
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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MLA
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Cain, D. W., & Cidlowski, J. A. (2017). Immune regulation by glucocorticoids. Nat Rev Immunol, 17(4), 233–247. https://doi.org/10.1038/nri.2017.1
Cain, Derek W., and John A. Cidlowski. “Immune regulation by glucocorticoids.Nat Rev Immunol 17, no. 4 (April 2017): 233–47. https://doi.org/10.1038/nri.2017.1.
Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017 Apr;17(4):233–47.
Cain, Derek W., and John A. Cidlowski. “Immune regulation by glucocorticoids.Nat Rev Immunol, vol. 17, no. 4, Apr. 2017, pp. 233–47. Pubmed, doi:10.1038/nri.2017.1.
Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017 Apr;17(4):233–247.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

April 2017

Volume

17

Issue

4

Start / End Page

233 / 247

Location

England

Related Subject Headings

  • Inflammation
  • Immunosuppressive Agents
  • Immunology
  • Immune System
  • Humans
  • Glucocorticoids
  • Animals
  • 3204 Immunology
  • 1107 Immunology