EMT and MET: necessary or permissive for metastasis?

Journal Article (Journal Article;Review)

Epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT/MET view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.

Full Text

Duke Authors

Cited Authors

  • Jolly, MK; Ware, KE; Gilja, S; Somarelli, JA; Levine, H

Published Date

  • July 2017

Published In

Volume / Issue

  • 11 / 7

Start / End Page

  • 755 - 769

PubMed ID

  • 28548345

Pubmed Central ID

  • PMC5496498

Electronic International Standard Serial Number (EISSN)

  • 1878-0261

Digital Object Identifier (DOI)

  • 10.1002/1878-0261.12083


  • eng

Conference Location

  • United States