Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.

Journal Article (Journal Article)

BACKGROUND: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. METHODS AND RESULTS: We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). CONCLUSIONS: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

Full Text

Duke Authors

Cited Authors

  • Ton, V-K; Bhonsale, A; Gilotra, NA; Halushka, MK; Steenbergen, C; Almansa, J; Brown, E; Tedford, RJ; Wittstein, I; Sharma, K; Russell, SD; Judge, DP

Published Date

  • April 2017

Published In

Volume / Issue

  • 23 / 4

Start / End Page

  • 340 - 344

PubMed ID

  • 28011000

Electronic International Standard Serial Number (EISSN)

  • 1532-8414

Digital Object Identifier (DOI)

  • 10.1016/j.cardfail.2016.12.006


  • eng

Conference Location

  • United States