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Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.

Publication ,  Journal Article
Diny, NL; Hou, X; Barin, JG; Chen, G; Talor, MV; Schaub, J; Russell, SD; Klingel, K; Rose, NR; Čiháková, D
Published in: Eur J Immunol
December 2016

Cardiac manifestations are a major cause of morbidity and mortality in patients with eosinophil-associated diseases. Eosinophils are thought to play a pathogenic role in myocarditis. We investigated the pathways that recruit eosinophils to the heart using a model of eosinophilic myocarditis, in which experimental autoimmune myocarditis (EAM) is induced in IFNγ-/- IL-17A-/- mice. Two conditions are necessary for efficient eosinophil trafficking to the heart: high eotaxin (CCL11, CCL24) expression in the heart and expression of the eotaxin receptor CCR3 by eosinophils. We identified cardiac fibroblasts as the source of CCL11 in the heart interstitium. CCL24 is produced by F4/80+ macrophages localized at inflammatory foci in the heart. Expression of CCL11 and CCL24 is controlled by Th2 cytokines, IL-4 and IL-13. To determine the relevance of this pathway in humans, we analyzed endomyocardial biopsy samples from myocarditis patients. Expression of CCL11 and CCL26 was significantly increased in eosinophilic myocarditis compared to chronic lymphocytic myocarditis and positively correlated with the number of eosinophils. Thus, eosinophil trafficking to the heart is dependent on the eotaxin-CCR3 pathway in a mouse model of EAM and associated with cardiac eotaxin expression in patients with eosinophilic myocarditis. Blocking this pathway may prevent eosinophil-mediated cardiac damage.

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Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

December 2016

Volume

46

Issue

12

Start / End Page

2749 / 2760

Location

Germany

Related Subject Headings

  • Th1-Th2 Balance
  • Receptors, CCR3
  • Nervous System Autoimmune Disease, Experimental
  • Myocardium
  • Myocarditis
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred BALB C
  • Mice
  • Male
 

Citation

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MLA
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Diny, N. L., Hou, X., Barin, J. G., Chen, G., Talor, M. V., Schaub, J., … Čiháková, D. (2016). Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart. Eur J Immunol, 46(12), 2749–2760. https://doi.org/10.1002/eji.201646557
Diny, Nicola L., Xuezhou Hou, Jobert G. Barin, Guobao Chen, Monica V. Talor, Julie Schaub, Stuart D. Russell, Karin Klingel, Noel R. Rose, and Daniela Čiháková. “Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.Eur J Immunol 46, no. 12 (December 2016): 2749–60. https://doi.org/10.1002/eji.201646557.
Diny NL, Hou X, Barin JG, Chen G, Talor MV, Schaub J, et al. Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart. Eur J Immunol. 2016 Dec;46(12):2749–60.
Diny, Nicola L., et al. “Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.Eur J Immunol, vol. 46, no. 12, Dec. 2016, pp. 2749–60. Pubmed, doi:10.1002/eji.201646557.
Diny NL, Hou X, Barin JG, Chen G, Talor MV, Schaub J, Russell SD, Klingel K, Rose NR, Čiháková D. Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart. Eur J Immunol. 2016 Dec;46(12):2749–2760.
Journal cover image

Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

December 2016

Volume

46

Issue

12

Start / End Page

2749 / 2760

Location

Germany

Related Subject Headings

  • Th1-Th2 Balance
  • Receptors, CCR3
  • Nervous System Autoimmune Disease, Experimental
  • Myocardium
  • Myocarditis
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred BALB C
  • Mice
  • Male