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Outcomes and predictors of recovery in acute-onset cardiomyopathy: A single-center experience of patients undergoing endomyocardial biopsy for new heart failure.

Publication ,  Journal Article
Gilotra, NA; Bennett, MK; Shpigel, A; Ahmed, HM; Rao, S; Dunn, JM; Harrington, C; Freitag, TB; Halushka, MK; Russell, SD
Published in: Am Heart J
September 2016

BACKGROUND: About one-third of patients with unexplained acute-onset heart failure (HF) recover left ventricular (LV) function; however, characterization of these patients in the setting of contemporary HF therapies is limited. We aim to describe baseline characteristics and predictors of recovery in patients with acute-onset cardiomyopathy. METHODS: We previously described 851 patients with unexplained HF undergoing endomyocardial biopsy. In this study, 235 patients with acute-onset HF were further retrospectively examined. RESULTS: Follow-up LV ejection fraction (LVEF) was available for 138 patients. At 1 year, 48 of 138 (33%) had LVEF recovery (follow-up LVEF ≥50%), and 90 of 138 (65%) had incomplete or lack of recovery. Higher cardiac index (P=.019), smaller LV diastolic diameter (P=.002), and lack of an intraventricular conduction delay (IVCD) (P=.002) were associated with LVEF recovery. IVCD (P=.001) and myocarditis (P=.016) were independent predictors of the composite end point of death, LV assist device placement, and/or transplant at 1 year. Those with an IVCD had a significantly lower 1-year survival than those without (P=.007). CONCLUSIONS: Patients with a smaller LV end-diastolic diameter, higher cardiac index, and lack of IVCD at presentation for acute-onset HF were more likely to have LVEF recovery. IVCD was a poor prognostic marker in all patients presenting with acute cardiomyopathy.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

September 2016

Volume

179

Start / End Page

116 / 126

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Retrospective Studies
  • Recovery of Function
  • Prognosis
  • Myocardium
  • Myocarditis
  • Multivariate Analysis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Gilotra, N. A., Bennett, M. K., Shpigel, A., Ahmed, H. M., Rao, S., Dunn, J. M., … Russell, S. D. (2016). Outcomes and predictors of recovery in acute-onset cardiomyopathy: A single-center experience of patients undergoing endomyocardial biopsy for new heart failure. Am Heart J, 179, 116–126. https://doi.org/10.1016/j.ahj.2016.06.019
Gilotra, Nisha A., Mosi K. Bennett, Adam Shpigel, Haitham M. Ahmed, Shaline Rao, Justin M. Dunn, Colleen Harrington, Tasha B. Freitag, Marc K. Halushka, and Stuart D. Russell. “Outcomes and predictors of recovery in acute-onset cardiomyopathy: A single-center experience of patients undergoing endomyocardial biopsy for new heart failure.Am Heart J 179 (September 2016): 116–26. https://doi.org/10.1016/j.ahj.2016.06.019.
Gilotra, Nisha A., et al. “Outcomes and predictors of recovery in acute-onset cardiomyopathy: A single-center experience of patients undergoing endomyocardial biopsy for new heart failure.Am Heart J, vol. 179, Sept. 2016, pp. 116–26. Pubmed, doi:10.1016/j.ahj.2016.06.019.
Gilotra NA, Bennett MK, Shpigel A, Ahmed HM, Rao S, Dunn JM, Harrington C, Freitag TB, Halushka MK, Russell SD. Outcomes and predictors of recovery in acute-onset cardiomyopathy: A single-center experience of patients undergoing endomyocardial biopsy for new heart failure. Am Heart J. 2016 Sep;179:116–126.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

September 2016

Volume

179

Start / End Page

116 / 126

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Retrospective Studies
  • Recovery of Function
  • Prognosis
  • Myocardium
  • Myocarditis
  • Multivariate Analysis
  • Middle Aged
  • Male