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Cardiac Index Declines During Long-Term Left Ventricular Device Support.

Publication ,  Journal Article
Kalathiya, RJ; Houston, BA; Chaisson, JM; Grimm, JC; Stevens, GR; Sciortino, CM; Shah, AS; Whitman, GJR; Russell, SD; Tedford, RJ
Published in: Artif Organs
December 2016

To investigate longitudinal trends in valvular and ventricular function with long-term left ventricular assist device (LVAD) therapy, we analyzed hemodynamic and echocardiographic data of patients with at least 2 years of continuous LVAD support. All 130 patients who underwent HeartMate II implantation at our institution between 2005 and 2012 were reviewed. Twenty patients had hemodynamic and echocardiographic evaluations in both the early (0-6 months) and late (2-3 years) postoperative period. Patients on inotropic therapy or temporary mechanical support were excluded. The average times of early and late hemodynamic evaluations were 59 ± 41 days and 889 ± 160 days, respectively. Cardiac index (CI) declined by an average of 0.4 L/min/m2 (P = 0.04) with concomitant increase in pulmonary capillary wedge pressure (PCWP; P = 0.02). The right atrial pressure to PCWP (RAP:PCWP) ratio decreased during LVAD support suggesting improvement in right ventricular function. While there was an increase in degree of aortic insufficiency (AI) at the late follow-up period (P = 0.008), dichotomization by median decline in CI (-0.4 L/min/m2 ) indicated no difference in prevalence of AI among the groups. CI declined in patients with HeartMate II after 2 years of continuous support. An increase in preload and afterload was observed in those with the greatest decline in CI.

Duke Scholars

Published In

Artif Organs

DOI

EISSN

1525-1594

Publication Date

December 2016

Volume

40

Issue

12

Start / End Page

1105 / 1112

Location

United States

Related Subject Headings

  • Prosthesis Implantation
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Hemodynamics
  • Heart-Assist Devices
  • Heart Ventricles
  • Heart Failure
  • Heart
 

Citation

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Kalathiya, R. J., Houston, B. A., Chaisson, J. M., Grimm, J. C., Stevens, G. R., Sciortino, C. M., … Tedford, R. J. (2016). Cardiac Index Declines During Long-Term Left Ventricular Device Support. Artif Organs, 40(12), 1105–1112. https://doi.org/10.1111/aor.12733
Kalathiya, Rohan J., Brian A. Houston, Jordan M. Chaisson, Joshua C. Grimm, Gerin R. Stevens, Christopher M. Sciortino, Ashish S. Shah, Glenn J. R. Whitman, Stuart D. Russell, and Ryan J. Tedford. “Cardiac Index Declines During Long-Term Left Ventricular Device Support.Artif Organs 40, no. 12 (December 2016): 1105–12. https://doi.org/10.1111/aor.12733.
Kalathiya RJ, Houston BA, Chaisson JM, Grimm JC, Stevens GR, Sciortino CM, et al. Cardiac Index Declines During Long-Term Left Ventricular Device Support. Artif Organs. 2016 Dec;40(12):1105–12.
Kalathiya, Rohan J., et al. “Cardiac Index Declines During Long-Term Left Ventricular Device Support.Artif Organs, vol. 40, no. 12, Dec. 2016, pp. 1105–12. Pubmed, doi:10.1111/aor.12733.
Kalathiya RJ, Houston BA, Chaisson JM, Grimm JC, Stevens GR, Sciortino CM, Shah AS, Whitman GJR, Russell SD, Tedford RJ. Cardiac Index Declines During Long-Term Left Ventricular Device Support. Artif Organs. 2016 Dec;40(12):1105–1112.
Journal cover image

Published In

Artif Organs

DOI

EISSN

1525-1594

Publication Date

December 2016

Volume

40

Issue

12

Start / End Page

1105 / 1112

Location

United States

Related Subject Headings

  • Prosthesis Implantation
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Hemodynamics
  • Heart-Assist Devices
  • Heart Ventricles
  • Heart Failure
  • Heart