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Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Publication ,  Journal Article
Prakasa, KR; Dalal, D; Wang, J; Bomma, C; Tandri, H; Dong, J; James, C; Tichnell, C; Russell, SD; Spevak, P; Corretti, M; Bluemke, DA ...
Published in: Am J Cardiol
March 1, 2006

Arrhythmogenic right ventricular dysplasia (ARVD/C) is a genetic cardiomyopathy characterized by fibrous fatty replacement of the right ventricular (RV) myocardium, leading to progressive RV failure and ventricular arrhythmias in young athletes. This study evaluated whether transthoracic, real-time, 3-dimensional echocardiography (3DE) can adequately assess RV morphology and function in ARVD/C by comparing 3DE with cardiac magnetic resonance (CMR), the current reference standard. Three-dimensional echocardiography was prospectively performed in 58 patients (23 with ARVD/C, 20 first-degree relatives with no ARVD/C, 8 with idiopathic ventricular tachycardia with no ARVD/C, and 7 healthy volunteers). All patients, except 15 patients with ARVD/C with implanted defibrillators, also underwent CMR. Three-dimensional echocardiography and CMR-derived RV volumes and ejection fractions were obtained by offline data analysis by blinded, independent observers. The mean age of the study group was 37 +/- 11 years (30 men). The feasibility of 3DE was high, and analyzable images were obtained in all subjects. Three-dimensional echocardiography revealed a wide variety of RV morphologic abnormalities in ARVD/C. There was a good correlation between 3DE and CMR for RV end-systolic volume (r = 0.72, p = 0.0001), RV end-diastolic volume (r = 0.50, p = 0.0001), and the RV ejection fraction (r = 0.88, p = 0.001). We found high intraobserver and moderate interobserver correlations for 3DE estimations of volumes and ejection fractions. In conclusion, 3DE measurements of RV volumes and ejection fractions closely correlate with CMR values and may be useful in the follow-up of patients with ARVD/C.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

March 1, 2006

Volume

97

Issue

5

Start / End Page

703 / 709

Location

United States

Related Subject Headings

  • Stroke Volume
  • Radiography
  • Prospective Studies
  • Observer Variation
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Image Processing, Computer-Assisted
  • Image Interpretation, Computer-Assisted
  • Humans
 

Citation

APA
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ICMJE
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Prakasa, K. R., Dalal, D., Wang, J., Bomma, C., Tandri, H., Dong, J., … Abraham, T. P. (2006). Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol, 97(5), 703–709. https://doi.org/10.1016/j.amjcard.2005.11.020
Prakasa, Kalpana R., Darshan Dalal, Jianwen Wang, Chandra Bomma, Harikrishna Tandri, Jun Dong, Cynthia James, et al. “Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.Am J Cardiol 97, no. 5 (March 1, 2006): 703–9. https://doi.org/10.1016/j.amjcard.2005.11.020.
Prakasa KR, Dalal D, Wang J, Bomma C, Tandri H, Dong J, et al. Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2006 Mar 1;97(5):703–9.
Prakasa, Kalpana R., et al. “Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.Am J Cardiol, vol. 97, no. 5, Mar. 2006, pp. 703–09. Pubmed, doi:10.1016/j.amjcard.2005.11.020.
Prakasa KR, Dalal D, Wang J, Bomma C, Tandri H, Dong J, James C, Tichnell C, Russell SD, Spevak P, Corretti M, Bluemke DA, Calkins H, Abraham TP. Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2006 Mar 1;97(5):703–709.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

March 1, 2006

Volume

97

Issue

5

Start / End Page

703 / 709

Location

United States

Related Subject Headings

  • Stroke Volume
  • Radiography
  • Prospective Studies
  • Observer Variation
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Image Processing, Computer-Assisted
  • Image Interpretation, Computer-Assisted
  • Humans