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Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Publication ,  Journal Article
Prakasa, KR; Wang, J; Tandri, H; Dalal, D; Bomma, C; Chojnowski, R; James, C; Tichnell, C; Russell, S; Judge, D; Corretti, M; Bluemke, D ...
Published in: Am J Cardiol
August 1, 2007

Arrhythmogenic right ventricular dysplasia (ARVD) is a heritable cardiomyopathy characterized by the fibrofatty replacement of right ventricular (RV) myocardium leading to RV failure and arrhythmias. This study evaluated the potential utility of tissue Doppler echocardiography (TDE) and strain echocardiography (SE) to quantitatively assess RV function and their potential role in diagnosing ARVD. Images of 30 patients with ARVD (diagnosed by task force criteria) and 36 healthy controls were obtained. Peak systolic velocity, early diastolic velocity, displacement, strain rate, strain, outflow tract diameter, and fractional RV area change were measured in all subjects. Peak RV systolic velocity (6.4 +/- 2.2 vs 9 +/- 1.6 cm/s, p <0.0001), early diastolic velocity (-6.7 +/- 2.7 vs -9.4 +/- 2 cm/s, p <0.0001), displacement (13.7 +/- 5.8 vs 18.7 +/- 3.5 mm, p <0.0003), strain rate (-1 +/- 0.7 vs -2 +/- 1 s(-1), p = 0.002), and strain (-10 +/- 6% vs -28 +/- 11%, p = 0.001) were significantly lower in patients with ARVD compared with controls, respectively. Sensitivity and specificity, respectively, were 67% and 89% for systolic velocity, 77% and 71% for displacement, 73% and 87% for strain, 50% and 96% for strain rate, 53% and 93% for outflow tract diameter, and 47% and 83% for fractional area change. RV systolic velocity and displacement were significantly lower than in controls, even in the subset of patients with ARVD with apparently normal right ventricles by conventional echocardiography. Inter- and intraobserver agreement was high. In conclusion, TDE and SE enable the detection of ARVD via the quantification of RV function and may have potential clinical value in the assessment of patients with suspected ARVD. Peak RV systolic velocity <7.5 cm/s and peak RV strain <18% best identify patients with ARVD.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

August 1, 2007

Volume

100

Issue

3

Start / End Page

507 / 512

Location

United States

Related Subject Headings

  • Ventricular Function, Right
  • Sensitivity and Specificity
  • Observer Variation
  • Male
  • Humans
  • Female
  • Electrocardiography
  • Echocardiography, Doppler
  • Echocardiography
  • Cardiovascular System & Hematology
 

Citation

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Prakasa, K. R., Wang, J., Tandri, H., Dalal, D., Bomma, C., Chojnowski, R., … Abraham, T. P. (2007). Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol, 100(3), 507–512. https://doi.org/10.1016/j.amjcard.2007.03.053
Prakasa, Kalpana R., Jianwen Wang, Harikrishna Tandri, Darshan Dalal, Chandra Bomma, Roman Chojnowski, Cynthia James, et al. “Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.Am J Cardiol 100, no. 3 (August 1, 2007): 507–12. https://doi.org/10.1016/j.amjcard.2007.03.053.
Prakasa KR, Wang J, Tandri H, Dalal D, Bomma C, Chojnowski R, et al. Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2007 Aug 1;100(3):507–12.
Prakasa, Kalpana R., et al. “Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.Am J Cardiol, vol. 100, no. 3, Aug. 2007, pp. 507–12. Pubmed, doi:10.1016/j.amjcard.2007.03.053.
Prakasa KR, Wang J, Tandri H, Dalal D, Bomma C, Chojnowski R, James C, Tichnell C, Russell S, Judge D, Corretti M, Bluemke D, Calkins H, Abraham TP. Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2007 Aug 1;100(3):507–512.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

August 1, 2007

Volume

100

Issue

3

Start / End Page

507 / 512

Location

United States

Related Subject Headings

  • Ventricular Function, Right
  • Sensitivity and Specificity
  • Observer Variation
  • Male
  • Humans
  • Female
  • Electrocardiography
  • Echocardiography, Doppler
  • Echocardiography
  • Cardiovascular System & Hematology