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The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences.

Publication ,  Journal Article
Heidecker, B; Lamirault, G; Kasper, EK; Wittstein, IS; Champion, HC; Breton, E; Russell, SD; Hall, J; Kittleson, MM; Baughman, KL; Hare, JM
Published in: Eur Heart J
May 2010

AIMS: We sought to test the hypothesis that inherent biological factors contribute to gender differences in disease pathophysiology of new-onset heart failure (HF), which can be detected from the transcriptome of a single endomyocardial biopsy (EMB). METHODS AND RESULTS: We analysed samples from male (n = 29) and female patients (n = 14) with idiopathic dilated cardiomyopathy (IDCM) and new-onset HF with U133 Plus 2.0 microarrays (Affymetrix) and significance analysis of microarrays (SAM). There were 35 overexpressed and 16 downregulated transcripts in men vs. women [q < 5%, fold change (FC) > 1.2]. In addition to overexpression of Y-chromosome-related transcripts (n = 18), such as USP9Y (FC > 13.1), DDX3Y (FC > 11.3), RPS4Y1 (FC > 9.9), and EIF1AY (FC > 11.8) in males, there was overexpression of CD24 (FC > 5.6) and KCNK1 (FC > 1.5). In females, XIST was highly overexpressed (FC > 28.9), together with X-linked zinc finger proteins (FC > 1.9) and autosomal genes GATAD1 (FC > 1.6), SLC2A12 (FC > 2.9), and PDE6B (FC > 1.5). Analysis of a public data set of end-stage IDCM (n = 15) resulted in approximately 85% overlap with our findings. CONCLUSION: This is the first study that identified gender-specific transcriptomic differences in new-onset HF. Our findings may offer novel insights into fundamental biological differences in the pathophysiology of HF between sexes and provide a platform for personalized medicine.

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Published In

Eur Heart J

DOI

EISSN

1522-9645

Publication Date

May 2010

Volume

31

Issue

10

Start / End Page

1188 / 1196

Location

England

Related Subject Headings

  • Transcription Factors
  • Stroke Volume
  • Sex Factors
  • Reverse Transcriptase Polymerase Chain Reaction
  • Microarray Analysis
  • Male
  • Humans
  • Heart Failure
  • Gene Expression
  • Female
 

Citation

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Heidecker, B., Lamirault, G., Kasper, E. K., Wittstein, I. S., Champion, H. C., Breton, E., … Hare, J. M. (2010). The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Eur Heart J, 31(10), 1188–1196. https://doi.org/10.1093/eurheartj/ehp549
Heidecker, Bettina, Guillaume Lamirault, Edward K. Kasper, Ilan S. Wittstein, Hunter C. Champion, Elayne Breton, Stuart D. Russell, et al. “The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences.Eur Heart J 31, no. 10 (May 2010): 1188–96. https://doi.org/10.1093/eurheartj/ehp549.
Heidecker B, Lamirault G, Kasper EK, Wittstein IS, Champion HC, Breton E, et al. The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Eur Heart J. 2010 May;31(10):1188–96.
Heidecker, Bettina, et al. “The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences.Eur Heart J, vol. 31, no. 10, May 2010, pp. 1188–96. Pubmed, doi:10.1093/eurheartj/ehp549.
Heidecker B, Lamirault G, Kasper EK, Wittstein IS, Champion HC, Breton E, Russell SD, Hall J, Kittleson MM, Baughman KL, Hare JM. The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Eur Heart J. 2010 May;31(10):1188–1196.
Journal cover image

Published In

Eur Heart J

DOI

EISSN

1522-9645

Publication Date

May 2010

Volume

31

Issue

10

Start / End Page

1188 / 1196

Location

England

Related Subject Headings

  • Transcription Factors
  • Stroke Volume
  • Sex Factors
  • Reverse Transcriptase Polymerase Chain Reaction
  • Microarray Analysis
  • Male
  • Humans
  • Heart Failure
  • Gene Expression
  • Female