Live kidney transplantation (LKT) is underutilized among patients with kidney disease. Social workers may be particularly effective in helping patients and their families overcome barriers to considering and/or pursuing LKT because of their expertise in helping families confront challenging social and medical issues. Nonetheless, social workers’ facilitation of patients’ consideration of LKT has not previously been reported. The team at Johns Hopkins University developed and tested the Talking about Live Kidney Donation (TALK) Social Worker Intervention to improve patients’ informed consideration of LKT. We provide practical guidelines for the implementation of the TALK Social Worker Intervention in clinical practice.