AHRQ series on complex intervention systematic reviews-paper 5: advanced analytic methods.

Journal Article (Journal Article)

BACKGROUND AND OBJECTIVE: Advanced analytic methods for synthesizing evidence about complex interventions continue to be developed. In this paper, we emphasize that the specific research question posed in the review should be used as a guide for choosing the appropriate analytic method. METHODS: We present advanced analytic approaches that address four common questions that guide reviews of complex interventions: (1) How effective is the intervention? (2) For whom does the intervention work and in what contexts? (3) What happens when the intervention is implemented? and (4) What decisions are possible given the results of the synthesis? CONCLUSION: The analytic approaches presented in this paper are particularly useful when each primary study differs in components, mechanisms of action, context, implementation, timing, and many other domains.

Full Text

Duke Authors

Cited Authors

  • Pigott, T; Noyes, J; Umscheid, CA; Myers, E; Morton, SC; Fu, R; Sanders-Schmidler, GD; Devine, B; Murad, MH; Kelly, MP; Fonnesbeck, C; Kahwati, L; Beretvas, SN

Published Date

  • October 2017

Published In

Volume / Issue

  • 90 /

Start / End Page

  • 37 - 42

PubMed ID

  • 28720512

Electronic International Standard Serial Number (EISSN)

  • 1878-5921

Digital Object Identifier (DOI)

  • 10.1016/j.jclinepi.2017.06.015


  • eng

Conference Location

  • United States