Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana.

Published

Journal Article

Limited data exist regarding the neonatal and neurodevelopmental outcomes of infants exposed to marijuana (MJ) in-utero, particularly among preterm infants. We hypothesized that MJ-exposed preterm infants would have worse neonatal and childhood developmental outcomes compared to MJ-unexposed infants.Secondary analysis of multicenter randomized-controlled trial of antenatal magnesium sulfate for the prevention of cerebral palsy was conducted. Singleton nonanomalous infants delivered <35 weeks exposed to MJ in-utero were compared to MJ-unexposed. Primary neonatal outcome was death, grade 3/4 intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, and/or stage II/III necrotizing enterocolitis before discharge. Primary childhood outcome was death, moderate/severe cerebral palsy, or/and Bayley II Scales <70 at age 2. Backward-stepwise regression used to estimate odds of primary outcomes.1867 infants met inclusion criteria; 135(7.2%) were MJ-exposed. There were no differences in neonatal (20% vs. 26%, p = 0.14) or childhood (26% vs. 21%, p = 0.21) outcomes in MJ-exposed infants compared to MJ-unexposed infants. In adjusted models, MJ-exposure was not associated with adverse neonatal outcomes (aOR 0.83 95% CI 0.47,1.44) or early childhood outcomes (aOR 1.47, 95% CI 0.97,2.23).Among infants born <35 weeks of gestation, MJ-exposure was not associated with adverse neonatal or childhood outcomes. Long-term follow-up studies are needed to assess later childhood neurodevelopmental outcomes following MJ-exposure.

Full Text

Duke Authors

Cited Authors

  • Dotters-Katz, SK; Smid, MC; Manuck, TA; Metz, TD

Published Date

  • December 2017

Published In

Volume / Issue

  • 30 / 24

Start / End Page

  • 2933 - 2939

PubMed ID

  • 27921445

Pubmed Central ID

  • 27921445

Electronic International Standard Serial Number (EISSN)

  • 1476-4954

International Standard Serial Number (ISSN)

  • 1476-7058

Digital Object Identifier (DOI)

  • 10.1080/14767058.2016.1269165

Language

  • eng