An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials.
We propose an empirical Bayes method for evaluating overall and study-specific treatment effects in multivariate meta-analysis with binary outcome. Instead of modeling transformed proportions or risks via commonly used multivariate general or generalized linear models, we directly model the risks without any transformation. The exact posterior distribution of the study-specific relative risk is derived. The hyperparameters in the posterior distribution can be inferred through an empirical Bayes procedure. As our method does not rely on the choice of transformation, it provides a flexible alternative to the existing methods and in addition, the correlation parameter can be intuitively interpreted as the correlation coefficient between risks.
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- Statistics & Probability
- 4905 Statistics
- 0199 Other Mathematical Sciences
- 0104 Statistics
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Statistics & Probability
- 4905 Statistics
- 0199 Other Mathematical Sciences
- 0104 Statistics