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An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials.

Publication ,  Journal Article
Chen, Y; Luo, S; Chu, H; Su, X; Nie, L
Published in: Commun Stat Theory Methods
July 29, 2014

We propose an empirical Bayes method for evaluating overall and study-specific treatment effects in multivariate meta-analysis with binary outcome. Instead of modeling transformed proportions or risks via commonly used multivariate general or generalized linear models, we directly model the risks without any transformation. The exact posterior distribution of the study-specific relative risk is derived. The hyperparameters in the posterior distribution can be inferred through an empirical Bayes procedure. As our method does not rely on the choice of transformation, it provides a flexible alternative to the existing methods and in addition, the correlation parameter can be intuitively interpreted as the correlation coefficient between risks.

Duke Scholars

Published In

Commun Stat Theory Methods

DOI

ISSN

0361-0926

Publication Date

July 29, 2014

Volume

43

Issue

16

Start / End Page

3536 / 3551

Location

United States

Related Subject Headings

  • Statistics & Probability
  • 4905 Statistics
  • 0199 Other Mathematical Sciences
  • 0104 Statistics
 

Citation

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ICMJE
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Chen, Y., Luo, S., Chu, H., Su, X., & Nie, L. (2014). An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials. Commun Stat Theory Methods, 43(16), 3536–3551. https://doi.org/10.1080/03610926.2012.700379
Chen, Yong, Sheng Luo, Haitao Chu, Xiao Su, and Lei Nie. “An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials.Commun Stat Theory Methods 43, no. 16 (July 29, 2014): 3536–51. https://doi.org/10.1080/03610926.2012.700379.
Chen Y, Luo S, Chu H, Su X, Nie L. An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials. Commun Stat Theory Methods. 2014 Jul 29;43(16):3536–51.
Chen, Yong, et al. “An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials.Commun Stat Theory Methods, vol. 43, no. 16, July 2014, pp. 3536–51. Pubmed, doi:10.1080/03610926.2012.700379.
Chen Y, Luo S, Chu H, Su X, Nie L. An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials. Commun Stat Theory Methods. 2014 Jul 29;43(16):3536–3551.
Journal cover image

Published In

Commun Stat Theory Methods

DOI

ISSN

0361-0926

Publication Date

July 29, 2014

Volume

43

Issue

16

Start / End Page

3536 / 3551

Location

United States

Related Subject Headings

  • Statistics & Probability
  • 4905 Statistics
  • 0199 Other Mathematical Sciences
  • 0104 Statistics