The Use of Whole Body Cooling in the Treatment of Hypoxic-Ischemic Encephalopathy.


Journal Article (Review)

Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in neonates. Hypoxic-ischemic encephalopathy occurs as a result of a perinatal hypoxic-ischemic event just prior to or during delivery. Therapeutic hypothermia using whole body cooling is the current treatment of choice to reduce brain injury and improve long-term neurodevelopmental outcomes for neonates with HIE. All English language articles published since 2005 in PubMed and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) were analyzed for existing evidence-based methods for whole body cooling. Whole body cooling is effective in the treatment of HIE in term and near-term neonates. Further research is needed to investigate the use of adjunctive therapies in conjunction with whole body cooling for improved neuroprotection.

Full Text

Cited Authors

  • Harriman, T; Bradshaw, WT; Blake, SM

Published Date

  • September 2017

Published In

Volume / Issue

  • 36 / 5

Start / End Page

  • 273 - 279

PubMed ID

  • 28847350

Pubmed Central ID

  • 28847350

Electronic International Standard Serial Number (EISSN)

  • 1539-2880

International Standard Serial Number (ISSN)

  • 0730-0832

Digital Object Identifier (DOI)

  • 10.1891/0730-0832.36.5.273


  • eng