Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.

Journal Article (Journal Article;Review)

The human leukocyte antigen (HLA) system is an important immunologic barrier that must be considered for successful solid organ transplantation. Formation of donor-specific HLA antibodies in solid organ transplantation is an important cause of allograft injury and may contribute to recipient morbidity and mortality. Therapeutic plasma exchange is often requested to lower HLA antibody levels prior to or after transplantation and for management of HLA antibodies in the context of organ rejection. In this review, we summarize the current terminology, laboratory testing, and clinical significance of HLA sensitization in the solid organ transplant population. Furthermore, to illustrate applications of HLA testing in clinical practice, we summarize our own lung and kidney institutional protocols for managing HLA antibodies in the peri-transplant setting.

Full Text

Duke Authors

Cited Authors

  • Abbes, S; Metjian, A; Gray, A; Martinu, T; Snyder, L; Chen, D-F; Ellis, M; Arepally, GM; Onwuemene, O

Published Date

  • October 2017

Published In

Volume / Issue

  • 21 / 5

Start / End Page

  • 441 - 450

PubMed ID

  • 28880430

Pubmed Central ID

  • PMC6890204

Electronic International Standard Serial Number (EISSN)

  • 1744-9987

Digital Object Identifier (DOI)

  • 10.1111/1744-9987.12570


  • eng

Conference Location

  • Australia