Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior.

Published

Journal Article

Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior.

Full Text

Duke Authors

Cited Authors

  • O'Hare, JK; Li, H; Kim, N; Gaidis, E; Ade, K; Beck, J; Yin, H; Calakos, N

Published Date

  • September 5, 2017

Published In

Volume / Issue

  • 6 /

PubMed ID

  • 28871960

Pubmed Central ID

  • 28871960

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

International Standard Serial Number (ISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.26231

Language

  • eng