Metabolomics applied to islet nutrient sensing mechanisms.
Journal Article (Journal Article;Review)
After multiple decades of investigation, the precise mechanisms involved in fuel-stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of "metabolomics," involving mass spectrometry and nuclear magnetic resonance-based profiling of islet cells in their fuel-stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose-stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.
Full Text
Duke Authors
Cited Authors
- Jensen, MV; Gooding, JR; Ferdaoussi, M; Dai, X-Q; Peterson, BS; MacDonald, PE; Newgard, CB
Published Date
- September 2017
Published In
Volume / Issue
- 19 Suppl 1 /
Start / End Page
- 90 - 94
PubMed ID
- 28880482
Pubmed Central ID
- PMC5929146
Electronic International Standard Serial Number (EISSN)
- 1463-1326
Digital Object Identifier (DOI)
- 10.1111/dom.13010
Language
- eng
Conference Location
- England