Metabolomics applied to islet nutrient sensing mechanisms.

Journal Article (Journal Article;Review)

After multiple decades of investigation, the precise mechanisms involved in fuel-stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of "metabolomics," involving mass spectrometry and nuclear magnetic resonance-based profiling of islet cells in their fuel-stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose-stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.

Full Text

Duke Authors

Cited Authors

  • Jensen, MV; Gooding, JR; Ferdaoussi, M; Dai, X-Q; Peterson, BS; MacDonald, PE; Newgard, CB

Published Date

  • September 2017

Published In

Volume / Issue

  • 19 Suppl 1 /

Start / End Page

  • 90 - 94

PubMed ID

  • 28880482

Pubmed Central ID

  • PMC5929146

Electronic International Standard Serial Number (EISSN)

  • 1463-1326

Digital Object Identifier (DOI)

  • 10.1111/dom.13010

Language

  • eng

Conference Location

  • England