Lack of effect of ammonium glycyrrhizinate on the morphology of ovine nasal mucosa in vitro.


Journal Article

Glycyrrhetinic acid derivatives are reported to be nasal absorption promoters (1). Effects of ammonium glycyrrhizinate (AMGZ) on the in vitro morphology of ovine nasal mucosa were therefore examined by light and electron microscopy. Nasal mucosa was stripped from the submucosa and mounted in Ussing chambers. Exposure of the apical surface to 2% ammonium glycyrrhizinate (24 mM) for 90 min caused no histopathological changes to the nasal epithelium. Epithelial integrity remained intact as evidenced by the continued presence of morphologically intact junctional complexes. No sloughing of the epithelial layer from the basement membrane was observed, and cilia and microvilli were not affected by treatment with AMGZ. The results indicate that short-term exposure in vitro to ammonium glycyrrhizinate caused no overt morphological damage to ovine nasal mucosa.

Full Text

Cited Authors

  • Reardon, PM; Wall, DA; Hart, TK; Smith, PL; Gochoco, CH

Published Date

  • September 1, 1993

Published In

Volume / Issue

  • 10 / 9

Start / End Page

  • 1301 - 1307

PubMed ID

  • 8234167

Pubmed Central ID

  • 8234167

Electronic International Standard Serial Number (EISSN)

  • 1573-904X

International Standard Serial Number (ISSN)

  • 0724-8741

Digital Object Identifier (DOI)

  • 10.1023/a:1018965612638


  • eng