Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.

Published

Journal Article

Inflammation is a risk factor for prostate cancer, but the mechanisms by which inflammation increases that risk are poorly understood. Here, we demonstrate that low expression of CD38 identifies a progenitor-like subset of luminal cells in the human prostate. CD38lo luminal cells are enriched in glands adjacent to inflammatory cells and exhibit epithelial nuclear factor κB (NF-κB) signaling. In response to oncogenic transformation, CD38lo luminal cells can initiate human prostate cancer in an in vivo tissue-regeneration assay. Finally, the CD38lo luminal phenotype and gene signature are associated with disease progression and poor outcome in prostate cancer. Our results suggest that prostate inflammation expands the pool of progenitor-like target cells susceptible to tumorigenesis.

Full Text

Duke Authors

Cited Authors

  • Liu, X; Grogan, TR; Hieronymus, H; Hashimoto, T; Mottahedeh, J; Cheng, D; Zhang, L; Huang, K; Stoyanova, T; Park, JW; Shkhyan, RO; Nowroozizadeh, B; Rettig, MB; Sawyers, CL; Elashoff, D; Horvath, S; Huang, J; Witte, ON; Goldstein, AS

Published Date

  • December 6, 2016

Published In

Volume / Issue

  • 17 / 10

Start / End Page

  • 2596 - 2606

PubMed ID

  • 27926864

Pubmed Central ID

  • 27926864

Electronic International Standard Serial Number (EISSN)

  • 2211-1247

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2016.11.010

Language

  • eng

Conference Location

  • United States