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Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.

Publication ,  Journal Article
Shih, Y-R; Phadke, A; Yamaguchi, T; Kang, H; Inoue, N; Masuda, K; Varghese, S
Published in: Acta Biomater
June 2015

Advances in tissue engineering have offered new opportunities to restore anatomically and functionally compromised tissues. Although traditional tissue engineering approaches that utilize biomaterials and cells to create tissue constructs for implantation or biomaterials as a scaffold to deliver cells are promising, strategies that can activate endogenous cells to promote tissue repair are more clinically attractive. Here, we demonstrate that an engineered injectable matrix mimicking a calcium phosphate (CaP)-rich bone-specific microenvironment can recruit endogenous cells to form bone tissues in vivo. Comparison of matrix alone with that of bone marrow-soaked or bFGF-soaked matrix demonstrates similar extent of neo-bone formation and bridging of decorticated transverse processes in a posterolateral lumbar fusion rat model. Synthetic biomaterials that stimulate endogenous cells without the need for biologics to assist tissue repair could circumvent limitations associated with conventional tissue engineering approaches, including ex vivo cell processing and laborious efforts, thereby accelerating the translational aspects of regenerative medicine.

Duke Scholars

Published In

Acta Biomater

DOI

EISSN

1878-7568

Publication Date

June 2015

Volume

19

Start / End Page

1 / 9

Location

England

Related Subject Headings

  • Tissue Scaffolds
  • Rats, Nude
  • Rats
  • Osteogenesis
  • Materials Testing
  • Male
  • Femoral Fractures
  • Equipment Failure Analysis
  • Equipment Design
  • Calcium Phosphates
 

Citation

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MLA
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Shih, Y.-R., Phadke, A., Yamaguchi, T., Kang, H., Inoue, N., Masuda, K., & Varghese, S. (2015). Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. Acta Biomater, 19, 1–9. https://doi.org/10.1016/j.actbio.2015.03.017
Shih, Yu-Ru, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, and Shyni Varghese. “Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.Acta Biomater 19 (June 2015): 1–9. https://doi.org/10.1016/j.actbio.2015.03.017.
Shih Y-R, Phadke A, Yamaguchi T, Kang H, Inoue N, Masuda K, et al. Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. Acta Biomater. 2015 Jun;19:1–9.
Shih, Yu-Ru, et al. “Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.Acta Biomater, vol. 19, June 2015, pp. 1–9. Pubmed, doi:10.1016/j.actbio.2015.03.017.
Shih Y-R, Phadke A, Yamaguchi T, Kang H, Inoue N, Masuda K, Varghese S. Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. Acta Biomater. 2015 Jun;19:1–9.
Journal cover image

Published In

Acta Biomater

DOI

EISSN

1878-7568

Publication Date

June 2015

Volume

19

Start / End Page

1 / 9

Location

England

Related Subject Headings

  • Tissue Scaffolds
  • Rats, Nude
  • Rats
  • Osteogenesis
  • Materials Testing
  • Male
  • Femoral Fractures
  • Equipment Failure Analysis
  • Equipment Design
  • Calcium Phosphates